Finally, a Management Option for the Millions of People Suffering from Chronic Venous Disease (CVD)

For the Clinical Dietary Management of the Metabolic Processes of Chronic Venous Disease (CVD)


Chronic Venous Disease (CVD) is a chronic, progressive disease of the veins that can lead to a variety of health issues such as leg edema (fluid retention), varicose veins, leg ulcers, stasis dermatitis (skin disease leading to ulcers), hemorrhoids.

The purified diosmin (diosmiplex) in Vasculera, a flavonoid that manages the body’s micro-circulation, works on the uncomfortable, embarrassing, and potentially debilitating symptoms caused by CVD. Studies have shown that the diosmin in Vasculera provides patients with significant improvements in CVD manifestations and quality of life.


Vasculera is dispensed by prescription and is to be used under a physician's supervision.


Vasculera is Derived from Natural Molecules

Vasculera is a prescription medical food containing highly-purified diosmin, an ingredient that has been designated “generally recognized as safe” (GRAS), the highest standard of safety at the FDA. Diosmin is a flavonoid isolated from hesperidin, found in citrus, that manages the body's microcirculatory balance. You would need to eat approximately 140 oranges a day (rind included) to consume the equivalent amount of diosmin packed into a single, easy-to-swallow Vasculera tablet.

Diosmin has been used globally for more than 30 years and is recommended in clinical-practice guidelines, supported by a body of evidence and world-renowned vascular experts.

Vasculera’s proprietary formula combines diosmin with alka-4 complex (diosmiplex). Alka-4 complex works with diosmin to manage venous inflammation and also counters the local acidosis produced in venous disease.

How to Take Vasculera

The recommended intake of Vasculera (diosmiplex) is 1 tablet daily for the dietary management of Chronic Venous Disease (CVD), manifested as: varicose/spider veins, edema, stasis dermatitis and or venous ulcers. Results may appear in as little as one week, but may not be seen for 4-to-8 weeks. For venous ulcers, results may not be seen for several months.

For hemorrhoidal disease (a manifestation of CVD), the recommended initial intake is 1 tablet 3 times daily for 4 days followed by 1 tablet twice daily for 9 days, or as directed by a physician. For hemorrhoidal discomfort persisting after resolution of the acute flare or for recurrent hemorrhoidal flares irrespective of persisting discomfort, a maintenance intake of one tablet of Vasculera daily is recommended.

Please see the Vasculera product information insert for further information.

Click to Get Information Tailored to Your Needs




Primus Care Direct is a hassle-free, mail-order pharmacy service where patients can get their Vasculera prescription for $49* (Medicare patients included). This is the lowest possible price available and includes free home delivery. If you have insurance, you may pay even less.

In addition to patient savings and convenience, Primus Care Direct saves time for healthcare practitioners by helping to increase fill rates and eliminating call-backs for prior authorizations.

Vasculera is also available at retail pharmacies, but Primus Care Direct guarantees patients will pay the lowest possible price on their prescription.

*Offer based on 30-day supply at prescribed one tablet per day dose


Advocating for Better Access to Vasculera

Without affordable access to Vasculera, and other prescription medical foods, patients will suffer. This is why Primus Pharmaceuticals (makers of Vasculera) started an advocacy movement to help patients, families, caregivers, healthcare providers and others have a voice to take control of their health with better access to safer medicines.

Increasingly, Medicare, Medicaid, Tricare and commercial health plans will only cover expensive synthetic drugs that merely treat symptoms and can cause serious adverse events.

Due to their safety profile and lack of drug-on-drug interaction, medical foods are often prescribed for chronic conditions in patient populations that have other diseases increasing their health risks from side effects associated with traditional drugs. It’s time to create real healthcare reform and usher in a better way to improve the quality of life for Americans suffering from chronic diseases like CVD.